School of Engineering, Shantou University has been working on EIP-CDIO (Ethics, Integrity, Professionalism, Conceive, Design, Implement, Operate) engineering education and training mode reform since 2005, whose main purpose is to cultivate student’s personal ability including self-learning, creation, team work, systematic adaptation and control. In order to guarantee quality of EIP-CDIO education, as well as bring teaching quality control and management in line with international standards step by step, we apply ISO Standards in teaching, administration and student management in our school. Taking our actual situation into consideration, we prepared four manuals: Quality Manual, Administration Manual, Teaching Manual and Student Management Manual. As a result, we were granted ISO19001:2000 (quality management system) and ISO 14001:2004 (environmental management system) certifications by TÜV Rheinland in April 2008. This paper describes how to construct quality assurance system for EIP-CDIO training mode based on ISO. Eight principles of ISO are descried in detail in how they are applied in education reform.