Our school, the school of Information Technology, University of Science, Vietnam National University – Ho Chi Minh, has been selected as one of the three schools in Vietnam to implement CDIO framework to improve our teaching and learning quality. The project will last for 7 years, which is fully supported by the government in an effort to make a model for other schools in Vietnam later on. Until now, it has gone through 2 years with a lot of positive changes in the teaching and learning. Although the project is still at the early stage and a lot of work need to be done in the coming years, lecturers and students are pleased with what they have experienced. The paper shares the experience and results that we have in the last 2 years when applying CDIO framework to the School of Information Technology with 6 departments and a total of more than 2000 students. The paper also shows the selfevaluation rubrics on 12 CDIO standards of the school before applying CDIO, after 6 months, 1 year, and 2 years. The key contribution of the paper is to show the step by step approach to update and improve the school learning outcomes, the curriculum, and changes in course syllabi to reflect personal, inter-personal and CDIO skills.