Manufacturing Engineering Program with CDIO approach has been adopted at Faculty of Mechanical Engineering, Vietnam National University – Ho Chi Minh City University of Technology since 2010. Up to now, the CDIO skills have been integrated into the courses in the teaching process. The CDIO Syllabus with design-Implement experiences are done via 04 student projects of the program: Introduction to Engineering project, Machine design project, manufacturing engineering project and Capstone project. This paper introduced the teaching of Machine design course and Machine design project to achieve the intended learning outcomes. The learning outcomes of the course are achieved corresponding to teaching and learning activities, assessment methods. Assignments and seminar reports are integrated to help students achieve most of the outcomes of the course. E-learning system has supported a lot for teaching and learning process so that these activities can take place anytime and anywhere. Grade subject is evaluated not only through lecturer but also via using of rubrics for each student and student groups assess each other. To assess the achievement of intended learning outcomes based on the rubrics student survey, the results of teaching and learning activities and assessment methods respectively. After completing this subject, the machine design project will help students improve the CDIO skills through the building of a true model from their design drawings. The end of this paper is the analysis and assessment of results achieved through the active learning methods, experiential learning methods, integrated learning across design-implement experiences.